What are the similarities and differences between the books Pygmalion and Frankenstein?

You could start by viewing each (of the creatures) as a product of a controlling genius, who decides the form which he wishes to create. You could explore the character of this creator, and how the goal, for each, displays good or evil motives.

Then you could contrast the creatures themselves, and the success or failure of the experiments.

Just a jumping-off point. It's really up to you how you view and explain these experiments. Are they scientific? Are they moral?

Lots of options here.