Hi Raku, fancy meetin' you here
Well, I know you asked for people that have had this...and I don't, but I didn't want you to think that no one was paying attention to your question. I did do some research on Drusen and came up with a few things. (I hate getting my eyes dialted too!
) Anyway, I know this isn't really what you wanted, but I hope it helps some anyway.
This site basically gives information about Drusen and also has some graphics to see. It's pretty interesting and can give some of the other readers of this thread some insight.
These are excellent articals on the signs, complications, progression, treatment, prevention and more.
What are drusen?
Retina lines your eyeball the way rubber lines a tennis ball. Drusen are nodules beneath your retina in a layer is called Bruch’s membrane which lies beneath your retina and the adjacent retina pigment epithelium layer.
Drusen may be metabolic waste products from various layers of your retina (retina, retina pigment epithelium and choriocapillaris).
Fat accumulates in Bruch’s membrane with age. This may contribute to drusen.
Drusen occur in two forms:
Hard, small (less than 63um in diameter) drusen do not increase with age and do not predispose to macular degeneration.
Soft, large (more than 63 um in diameter) drusen enlarge and become confluent with age, may predispose to macular degeneration, are more commonly seen in eyes of people with advanced macular degeneration in their other eye.
Risk factors
Family history
UV and visible blue light
Animal studies suggest UV and visible blue light damage retina
No human clinical data establishes cause and effect between UV and visible blue light to macula degeneration, but there may be an association between increased visible light exposure during later years and macula drusen, but that study has not been confirmed by subsequent studies.
Causes or contributing factors
Idiopathic & spontaneous
Embryonic, congenital or developmental
Disorders of your eye
Disorders of your body
Disorders due to agents, toxins or drugs
Drusen can be confused with:
Cuticular drusen
Basal laminar drusen
Dominant drusen in young people
Pattern dystrophy of the Retina Pigment Epithelium
North Carolina fundus dystrophy
Fundus albi punctate dystrophy
Alport’s disease
Ring-17 chromosome retinopathy
Symptoms
Most people with drusen have no symptoms and suffer no complications
Most people who have drusen and suffer complications in one eye suffer no complications in the other eye
Drusen may affect contrast sensitivity
Drusen may affect reading in dim light
Drusen may affect driving at night
Signs
Focal or diffuse deposits in Bruch's membrane
Drusen may be:
Yellow, white, gray, refractile, pink
Small, medium or large
Regular or irregular
Symmetrical or asymmetrical
Complications
Hard, small drusen
none
Soft, large drusen
Retina pigment epithelium atrophy
Choroid neovascularization
Retina detachment serous
Retina detachment hemorrhagic
Aggravating conditions
Soft, large drusen in macula have greater risk of choroid neovascularization
Progression
Drusen enlarge and retina pigment epithelium layer thins.
Drusen become yellow or gray, but can be pink, crystalline, refractile
Drusen vary in size from small to large and irregular
Drusen increase in number and size but can fade and decrease in number
10% of people with soft, large drusen in each eye may develop destruction of retina pigment epithelium after five years
Evaluation
Eye health examination
Amsler grid
Treatment
No demonstrated clinically-effective treatment known.
Treatment under investigation include:
Laser of or around drusen can reduce drusen and improve vision
Choroidal Neovascular Prevention Trial showed argon green treatment reduced drusen but was associated with increased new blood vessel growth under the macula in the other eye three years after treatment.
Mild diode laser treatment reduced drusen without statistically-significant new blood vessel growth under the macula.
Complications of AMD Prevention Trial (CAPT) evaluates mild argon green laser photocoagulation in patients with drusen in both eyes. (
www.nei.nih.gov/neitrials)
Prophylactic Treatment of AMD Study (PTAMD) tests mild diode laser treatment of patients with drusen in both eyes and in one eye. (
www.irismedical.com)
Laser around macula
Diet
Age Related Eye Disease Study is a randomized, controlled prospective clinical trial that enrolled 4357 participants in four groups: placebo, antioxidants (vitamins C and E plus beta-carotene), zinc, antioxidants plus zinc. Analysis of data shows that high daily doses of vitamin C (500 mg) vitamin E (400 IU) beta carotene (15 mg) and zinc oxide (80 mg) may modestly reduce risk of progression (28% progression in untreated people reduced to 20% progression in treated people) of those who have intermediate-sized drusen, large drusen or non-central geographic atrophy or advanced macular degeneration in one eye.
Rheotherapy is the removal of high molecular weight molecules from your blood plasma, and may be associated with improved vision.
Multicenter Investigation of Rheopheresis for AMD (MIRA-1) is a prospective clinical trial in Phase III
Supplements
Zinc: oral zinc supplement may reduce vision loss in people with drusen or atrophic retina pigment epithelium after two years compared to placebo, but this is not confirmed by a larger study. Dosage, magnitude of effect and complications from zinc are not established.
Antioxidants (Vitamin C, E, carotenoids): while people with elevated blood antioxidant levels are half as likely to develop macula degeneration as those with lower levels, this does not imply cause and effect, nor does it imply that increased antioxidant consumption will reduce or reverse macula degeneration.
Prevention
Near vision card
Amsler grid
Factoids
No difference between men and women
Can develop in young adults and can progress
86% of white Chesapeake Bay watermen have hard drusen
13% of white Chesapeake Bay watermen over 50 years old have soft drusen
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